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Inherited combined deficiency of factor V and factor VIII: Report of a case with normal factor VIII antigen and ristocetin‐induced platelet aggregation
Author(s) -
Cimo P. L.,
Moake J. L.,
Gonzalez M. F.,
Natelson E. A.,
Fox K. R.
Publication year - 1977
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830020408
Subject(s) - ristocetin , platelet , antigen , medicine , von willebrand factor , endocrinology , platelet aggregation , von willebrand disease , immunology
A patient with inherited combined deficiency of factor V and factor VIII is reported, who demonstrated normal levels of factor VIII antigen and plasma co‐factor for ristocetin‐induced platelet aggregation. The relationship of this condition to classical hemophilia and von Willebrand's disease is discussed. The data presented suggest that multiple loci on at least 2 chromosomes are necessary for the normal expression of factor VIII activity.