Hb leiden‐β° thalassemia in a chinese with severe hemolytic anemia | Zendy

LieInjo Luan Eng | Zendy; Randhawa Z. I. | Zendy; Ganesan J. | Zendy; Peterson D. | Zendy; Kane J. P. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Hb leiden‐β° thalassemia in a chinese with severe hemolytic anemia

Author(s) -

LieInjo Luan Eng,

Randhawa Z. I.,

Ganesan J.,

Peterson D.,

Kane J. P.

Publication year - 1977

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830020403

Subject(s) - medicine , thalassemia , splenectomy , hemolytic anemia , brother , pediatrics , anemia , chinese family , compound heterozygosity , hemoglobin , blood transfusion , gastroenterology , mutation , genetics , gene , biology , spleen , sociology , anthropology

The first case of Hb Leiden (α 2 β 2 6 or 7 Glu→0 )‐β° thalassemia in a young patient with chronic severe hemolytic anemia, which improved after splenectomy, is described. His parents were Chinese. The patient's blood showed no Hb A or normal β chains when no blood transfusion was given. His mother was heterozygous for β° thalassemia, and his father and brother had the trait for the unstable Hb Leiden. The Hb Leiden level of the father was 22.6% and that of the brother was 19.3%. It is probable that the abnormal hemoglobin in this Chinese family resulted from an independent gene mutation, unrelated to the one found in 2 Caucasian families reported earlier.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research