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Development of chronic myelocytic leukemia during the course of acute lymphocytic leukemia in an adult
Author(s) -
Fisher Barry L.,
Lyons Roger M.,
Sears David A.
Publication year - 1977
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830020311
Subject(s) - medicine , prednisone , chronic lymphocytic leukemia , vincristine , myelocytic leukemia , acute lymphocytic leukemia , leukemia , bone marrow , myeloproliferative disorders , immunology , chemotherapy , cyclophosphamide , lymphoblastic leukemia
A 59‐year‐old patient is described who presented with acute lymphocytic leukemia. Complete remission was induced rapidly with vincristine and prednisone. Nine months later he acquired the clinical and hematological picture of a myeloproliferative disease, and bone marrow cytogenetic studies demonstrated the presence of the Philadelphia chromosome. Within 4 months he again developed overt acute lymphocytic leukemia and died. Several lines of evidence have recently indicated a relationship between myeloproliferative and lymphoproliferative disorders, particularly chronic myelocytic and acute lymphocytic leukemia. This patient's course is another example of that association.