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A family study of a patient with idiopathic hemochromatosis
Author(s) -
Miller Aaron,
Zimelman Abraham,
Brauer Mark J.
Publication year - 1977
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830020106
Subject(s) - transferrin saturation , hemochromatosis , hereditary hemochromatosis , asymptomatic , medicine , family history , pediatrics , iron deficiency , anemia
A family study of a patient with idiopathic hemochromatosis using noninvasive techniques is presented. All 6 of the patient's asymptomatic children had an increase in transferrin saturation and/or an increase in the absorption of Co 57 . The Co 57 absorption test was the most sensitive index of family involvement since one of the children had an increase in absorption at a time when transferring saturation was normal. The family data strongly support the hereditary nature of the disorder, with the mode of inheritance not clearly established from the available data.