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Inhibition of murine granulopoiesis in vitro by dexamethasone
Author(s) -
Golde David W.,
Bersch Noelle,
Quan Shirley G.,
Cline Martin J.
Publication year - 1976
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830010402
Subject(s) - granulopoiesis , dexamethasone , in vitro , medicine , pharmacology , cancer research , chemistry , biology , microbiology and biotechnology , haematopoiesis , biochemistry , stem cell
Abstract The effect of dexamethasone on mouse bone marrow granulocyte‐monocyte precursor cells (CFU‐C) was studied in vitro. Dexamethasone inhibited colony formation in the presence of maximally stimulating concentrations of colony‐stimulating activity. A mean colony reduction of 55% occurred at 10 9 M dexamethasone and inhibition was observed at concentrations as low as 10 −12 M. The dexamethasone suppression could be abrogated by progesterone. These studies provide evidence that the committed granulocyte‐monocyte stem cell has a glucocorticoid receptor mechanism that when activated results in inhibition of cellular proliferation in vitro.