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Pathogenesis of polycythemia vera—new concepts
Author(s) -
Golde David W.,
Cline Martin J.
Publication year - 1976
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830010311
Subject(s) - polycythemia vera , erythropoiesis , pathogenesis , erythropoietin , stem cell , cancer research , induced pluripotent stem cell , biology , medicine , immunology , microbiology and biotechnology , anemia , genetics , gene , embryonic stem cell
Data presently available suggest that polycythemia vera is an acquired clonal disorder of the pluripotent stem cell resulting in expansion of committed stem cell pools, most prominently in the erythroid line. In vitro and in vivo studies suggest that erythropoiesis in polycythemia vera is at least partially modulated by erythropoietin.