Premium
T and B lymphocytes in leukemia therapy
Author(s) -
Esber Elaine,
Dinicola William,
Movassaghi Nasser,
Leikin Sanford
Publication year - 1976
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830010205
Subject(s) - chemotherapy , immunology , leukemia , lymphocyte , medicine , antibody , receptor , b cell , peripheral blood
In order to evaluate the effect of radio‐ and chemotherapy on immunity, T and B lymphocyte surface receptors were studied sequentially in the blood from 28 previously untreated leukemic children. Following the initiation of chemotherapy an increase in the percent T and B cells was noted in the peripheral blood. In association with sanctuary therapy and chemotherapy there was a decrease in the total number of circulating T and B cells and a relative increase in lymphocytes lacking markers. Based on total numbers at remission the reduction in B cells was greater than in T cells, and the most marked changes occurred during sanctuary therapy. A reduction in the mean serum immunoglobulin was associated with decreasing B cell numbers.