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In vivo dissociation of factor vii (ahf) activity and factor viii‐related antigen in von willebrand's disease
Author(s) -
Lian Eric ChunYet,
Deykin Daniel
Publication year - 1976
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830010108
Subject(s) - antigen , von willebrand factor , proband , von willebrand disease , immunology , coagulopathy , medicine , disease , risk factor , endocrinology , chemistry , platelet , biochemistry , mutation , gene
Using monospecific rabbit antihuman factor VIII antiserum, we have examined the amounts of factor VIII‐related antigen and compared these to the levels of factor VIII procoagulant activity in normal subjects and patients with von Willebrand's disease. We have observed that even without transfusion all nine probands with von Willebrand's disease and 20 of their 34 relatives possessed a significantly elevated factor VIII activity/factor VIII‐related antigen ratio when compared to that of 55 normal subjects. It is suggested that an elevated factor VIII activity/factor VIII‐related antigen ratio may be used for detection of the carriers of von Willebrand's disease.