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A noncanonical FLT3 gatekeeper mutation disrupts gilteritinib binding and confers resistance
Author(s) -
Joshi Sunil K.,
Sharzehi Setareh,
Pittsenbarger Janét,
Bottomly Daniel,
Tog Cristina E.,
McWeeney Shan K.,
Druker Brian J.,
Traer Elie
Publication year - 2021
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.26174
Subject(s) - mutation , tyrosine kinase , cancer research , myeloid leukemia , protein kinase domain , fms like tyrosine kinase 3 , tyrosine kinase inhibitor , gene duplication , biology , chemistry , gene , genetics , signal transduction , cancer , mutant