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The transcriptome‐wide landscape of molecular subtype‐specific mRNA expression profiles in acute myeloid leukemia
Author(s) -
Mou Tian,
Pawitan Yudi,
Stahl Matthias,
Vesterlund Mattias,
Deng Wenjiang,
Jafari Rozbeh,
Bohlin Anna,
Österroos Albin,
Siavelis Loannis,
Bäckvall Helena,
Erkers Tom,
Kiviluoto Santeri,
SeashoreLudlow Brinton,
Östling Päivi,
Orre Lukas M.,
Kallioniemi Olli,
Lehmann Sören,
Lehtiö Janne,
Vu Trung Nghia
Publication year - 2021
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.26141
Subject(s) - transcriptome , myeloid leukemia , messenger rna , biology , computational biology , proteomics , myeloid , gene , gene expression , bioinformatics , cancer research , genetics
Abstract Molecular classification of acute myeloid leukemia (AML) aids prognostic stratification and clinical management. Our aim in this study is to identify transcriptome‐wide mRNAs that are specific to each of the molecular subtypes of AML. We analyzed RNA‐sequencing data of 955 AML samples from three cohorts, including the BeatAML project, the Cancer Genome Atlas, and a cohort of Swedish patients to provide a comprehensive transcriptome‐wide view of subtype‐specific mRNA expression. We identified 729 subtype‐specific mRNAs, discovered in the BeatAML project and validated in the other two cohorts. Using unique proteomics data, we also validated the presence of subtype‐specific mRNAs at the protein level, yielding a rich collection of potential protein‐based biomarkers for the AML community. To enable the exploration of subtype‐specific mRNA expression by the broader scientific community, we provide an interactive resource to the public.