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The complex karyotype and chronic lymphocytic leukemia: prognostic value and diagnostic recommendations
Author(s) -
Jondreville Ludovic,
Krzisch Daphné,
Chapiro Elise,
NguyenKhac Florence
Publication year - 2020
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.25956
Subject(s) - chemoimmunotherapy , chronic lymphocytic leukemia , medicine , karyotype , oncology , myeloid leukemia , myelodysplastic syndromes , leukemia , immunology , chromosome , biology , bone marrow , genetics , gene
Chromosomal abnormalities are frequently observed in patients with chronic lymphocytic leukemia (CLL) and have prognostic value. Deletions of the short arm of chromosome 17 (and/or mutations TP53 ) predict resistance to chemoimmunotherapy and shorter progression‐free survival after targeted therapies. Although the complex karyotype (CK) is strongly predictive of a poor prognosis in hematologic malignancies such acute myeloid leukemia or myelodysplastic syndrome, its value in CLL is subject to debate. Here, we review the literature on the CK in CLL and examine its prognostic value with different treatments. We also propose a standardized method for defining a CK in all types of hematopoietic neoplasm.