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Histological transformation to diffuse large B‐cell lymphoma in patients with Waldenström macroglobulinemia
Author(s) -
Castillo Jorge J.,
Gustine Joshua,
Meid Kirsten,
Dubeau Toni,
Hunter Zachary R.,
Treon Steven P.
Publication year - 2016
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.24477
Subject(s) - macroglobulinemia , waldenstrom macroglobulinemia , medicine , lymphoplasmacytic lymphoma , lymphoma , diffuse large b cell lymphoma , pathology , multiple myeloma
Histological transformation to diffuse large B‐cell lymphoma (DLBCL) rarely occurs in patients with Waldenström Macroglobulinemia (WM). We identified 20 patients out of a cohort of 1,466 WM patients who experienced histologic transformation. The 5, 10, and 15‐year cumulative incidence rates were 1, 2.4, and 3.8%, respectively. Approximately half of the patients were naive to nucleoside analogues, and a quarter were previously untreated for WM at the time of transformation. More than 80% of patients presented with extranodal involvement, 65% with high IPI scores. DLBCL cells did not express CD10 but expressed BCL6 and BCL2. All patients were treated with chemoimmunotherapy. The median survival from histological transformation was 2.7 years. The median overall survival was shorter for transformed patients versus those who did not transform (estimated 9 vs. 16 years; P = 0.09). Histological transformation to DLBCL is rare, and is associated with inferior survival in WM. Am. J. Hematol. 91:1032–1035, 2016. © 2016 Wiley Periodicals, Inc.