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Health‐related quality of life and burden of fatigue in patients with primary immune thrombocytopenia by phase of disease
Author(s) -
Efficace Fabio,
Mandelli Franco,
Fazi Paola,
Santoro Cristina,
Gaidano Gianluca,
Cottone Francesco,
Borchiellini Alessandra,
Carpenedo Monica,
Simula Maria Pina,
Di Giacomo Valeria,
Bergamaschi Micaela,
Vincelli Iolanda Donatella,
Rodeghiero Francesco,
Ruggeri Marco,
Scaramucci Laura,
Rambaldi Alessandro,
Cascavilla Nicola,
Forghieri Fabio,
Petrungaro Annamaria,
Ditonno Paolo,
Caocci Giovanni,
Cirrincione Sonia,
Mazzucconi Maria Gabriella
Publication year - 2016
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.24463
Subject(s) - medicine , quality of life (healthcare) , population , propensity score matching , observational study , sf 36 , health related quality of life , disease , physical therapy , nursing , environmental health
The main objective of this study was to compare health‐related quality of life (HRQOL) of primary immune thrombocytopenia (pITP) patients with that of general population, overall, and by patient group (i.e., newly diagnosed, persistent, and chronic patients). Fatigue was also investigated as a secondary objective. Overall, 424 adult patients were enrolled in a multicenter observational study and the control group consisted of a representative sample from the general population. Propensity score matching plus further multivariate linear regression adjustment was used to compare HRQOL outcomes between pITP patients and general population. Mean age of patients was 54 years. Of those with HRQOL assessment, 99 patients (23.6%) were newly diagnosed, 53 (12.6%) were persistent, and 268 (63.8%) were chronic pITP patients. Comparison by patient group versus their respective peers in the general population revealed greater impairments in persistent pITP patients. Persistent pITP patients reported clinically meaningful impairments in physical functioning (−15; 95% CI −24.1 to −5.8; P = 0.002), social functioning (−15.3; 95% CI −25.5 to −5.1; P = 0.004), role physical (−28.4; 95% CI −43.1 to −13.7; P < 0.001), role emotional (−23.9; 95% CI −40.1 to −7.7; P = 0.004), and mental health scales (−11.3; 95% CI −21.2 to −1.4; P = 0.026) of the SF‐36 questionnaire. Higher fatigue severity was associated with lower physical and mental HRQOL outcomes. Our findings suggest that the burden of the disease and treatment might depend on the disease phase and that persistent pITP patients are the most vulnerable subgroup. Am. J. Hematol. 91:995–1001, 2016. © 2016 Wiley Periodicals, Inc.