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Incidence, etiology, and outcome of pleural effusions in allogeneic hematopoietic stem cell transplantation
Author(s) -
Modi Dipenkumar,
Jang Hyejeong,
Kim Seongho,
Deol Abhinav,
Ayash Lois,
Bhutani Divaya,
Lum Lawrence G.,
Ratanatharathorn Voravit,
Manasa Richard,
Mellert Kendra,
Uberti Joseph P.
Publication year - 2016
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.24435
Subject(s) - medicine , pleural effusion , incidence (geometry) , cumulative incidence , hematopoietic stem cell transplantation , surgery , gastroenterology , comorbidity , etiology , transplantation , physics , optics
Pleural effusion is a known entity in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT); however, the incidence, risk factors, and morbidity−mortality outcomes associated with pleural effusions remain unknown. We retrospectively evaluated pleural effusions in 618 consecutive adult patients who underwent allogeneic HSCT from January 2008 to December 2013 at our institution. Seventy one patients developed pleural effusion at a median of 40 days (range, 1 − 869) post‐HSCT with the cumulative incidence of 9.9% (95% CI, 7.7 − 12.5%) at 1 year. Infectious etiology was commonly associated with pleural effusions followed by volume overload and serositis type chronic GVHD. In multivariate analysis, higher comorbidity index ( P = 0.03) and active GVHD ( P = 0.018) were found to be significant independent predictors for pleural effusion development. Higher comorbidity index, very high disease risk index, ≤7/8 HLA matching, and unrelated donor were associated with inferior overall survival (OS) ( P < 0.03). More importantly, patients with pleural effusion were noted to have poor OS in comparison to patients without pleural effusion ( P < 0.001). Overall, pleural effusion is a frequently occurring complication after allogeneic HSCT, adding to morbidity and mortality and hence, early identification is required. Am. J. Hematol. 91:E341–E347, 2016. © 2016 Wiley Periodicals, Inc.