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Chronic lymphocytic leukemia: Time to go past genomics?
Author(s) -
RoosWeil Damien,
NguyenKhac Florence,
Bernard Olivier A.
Publication year - 2016
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.24301
Subject(s) - chronic lymphocytic leukemia , somatic evolution in cancer , genomics , biology , computational biology , massive parallel sequencing , leukemia , gene , dna sequencing , genetics , genome
Recent advances in massively parallel sequencing technologies have provided a detailed picture of the mutational landscape in CLL and underscored the vast degree of interpatient and intratumor heterogeneities. These studies have led to the characterization of novel putative driver genes and recurrently affected biological pathways, and to the modeling of CLL clonal evolution. We herein review selected aspects including recent advances in the biology of CLL and present cellular and biological processes involved in the development of CLL and potentially other mature B‐cell lymphoproliferative neoplasms. Am. J. Hematol. 91:518–528, 2016. © 2016 Wiley Periodicals, Inc.