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Monoclonal anti‐transferrin antibody: A paradigm for better understanding of iron metabolism
Author(s) -
Ropert Martine,
Détivaud Lénaïck,
Fimbel d'Hauthuille Béatrice,
Gautier Mathilde,
Leroyer Patricia,
Jouanolle AnneMarie,
Loréal Olivier,
Brissot Pierre
Publication year - 2015
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.24004
Subject(s) - transferrin , hemochromatosis , transferrin receptor , ferritin , transferrin saturation , hereditary hemochromatosis , antibody , microbiology and biotechnology , monoclonal antibody , biochemistry , chemistry , biology , medicine , immunology , serum ferritin
International audienceA 82 years old patient was admitted for persisting abnormalities of iron metabolismparameters in the context IgG kappa monoclonal gammopathy, discovered 12 years before,and classified as MGUS (monoclonal gammopathy of undetermined significance). Serum ironand transferrin concentration were constantly extremely high (96.9 μmol/L and 5.0 g/L,respectively), transferrin saturation was elevated (77.5% ; N<45%) and serum ferritinmoderately increased (608μg/L ; N<300 μg/L). Hemochromatosis was ruled out(1) : no tissueiron overload was present and genetic studies searching for mutations in HFE and non HFEgenes, were negative (p.Cys282Tyr mutation, HJV (HFE2), HAMP, TFR2, BMP6, SLC40A1 andFTL)