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Bendamustine and rituximab combination in the management of chronic lymphocytic leukemia‐associated autoimmune hemolytic anemia: A multicentric retrospective study of the French CLL intergroup (GCFLLC/MW and GOELAMS)
Author(s) -
Quinquenel Anne,
Willekens Christophe,
Dupuis Jehan,
Royer Bruno,
Ysebaert Loic,
Guibert S. De,
Michallet AnneSophie,
Feugier Pierre,
Guieze Romain,
Levy Vincent,
Delmer Alain
Publication year - 2015
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.23909
Subject(s) - bendamustine , rituximab , medicine , autoimmune hemolytic anemia , chronic lymphocytic leukemia , anemia , leukemia , immunology , gastroenterology , oncology , lymphoma
We report our experience on bendamustine and rituximab (BR) combination in 26 patients with chronic lymphocytic leukemia (CLL) complicated by autoimmune hemolytic anemia (AIHA). At the time of BR initiation, 88% of the patients had already been treated for AIHA and CLL was progressive regardless of AIHA in all patients but one. Overall response rates were 81% for AIHA and 77% for CLL. Median time to next treatment was 28.3 months and 26.2 months for AIHA and CLL, respectively. BR therapy may represent a good and safe therapeutic option in this setting where adequate control of CLL seems important for long‐term AIHA response. Am. J. Hematol. 90:204–207, 2015. © 2014 Wiley Periodicals, Inc.