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Monocytic and promyelocytic myeloid‐derived suppressor cells may contribute to G ‐ CSF ‐induced immune tolerance in haplo‐identical allogeneic hematopoietic stem cell transplantation
Author(s) -
Lv Meng,
Zhao XiaoSu,
Hu Yue,
Chang YingJun,
Zhao XiangYu,
Kong Yuan,
Zhang XiaoHui,
Xu LanPing,
Liu KaiYan,
Huang XiaoJun
Publication year - 2015
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.23865
Subject(s) - myeloid derived suppressor cell , medicine , hematopoietic stem cell transplantation , haematopoiesis , immunology , cumulative incidence , immune system , stem cell , myeloid , transplantation , incidence (geometry) , bone marrow , gastroenterology , suppressor , biology , cancer , physics , optics , genetics
We investigated the effects of granulocyte colony‐stimulating factor (G‐CSF) on monocytic (M), promyelocytic (P), and granulocytic (G) myeloid‐derived suppressor cells (MDSCs) both in bone marrow and peripheral blood of 20 healthy donors and the association of MDSCs subgroups with acute and chronic graft‐versus‐host disease (aGvHD/cGvHD) in 62 patients who underwent haplo‐identical allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Patients who received a higher absolute counts of M‐MDSCs or P‐MDSCs exhibited lower incidence of grade II–IV aGvHD ( P = 0.001; P = 0.031) and extensive cGvHD ( P = 0.011; P = 0.021). In the multivariate analysis, absolute counts of MDSCs in allografts emerged as independent factors that reduced the occurrence of grade II–IV aGvHD (M‐MDSCs: HR = 0.087, 95% CI = 0.020–0.381, P = 0.001; P‐MDSCs: HR = 0.357, 95% CI = 0.139–0.922, P = 0.033) and extensive cGvHD (M‐MDSCs: HR = 0.196, 95% CI = 0.043–0.894, P = 0.035; P‐MDSCs: HR = 0.257, 95% CI = 0.070–0.942, P = 0.04). Delayed M‐MDSC reconstitution was associated with aGvHD onset. The 3‐year cumulative incidence of transplant related mortality and relapse, 3‐year probability of disease‐free survival, and overall survival did not differ significantly between these subgroups. Our results suggested that G‐CSF‐induced immune tolerance may be mediated by M/P‐MDSCs in allo‐HSCT. Am. J. Hematol. 90:E9–E16, 2015. © 2014 Wiley Periodicals, Inc.