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Autoimmune cytopenias in chronic lymphocytic leukemia
Author(s) -
Visco Carlo,
Barcellini Wilma,
Maura Francesco,
Neri Antonino,
Cortelezzi Agostino,
Rodeghiero Francesco
Publication year - 2014
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.23785
Subject(s) - autoimmune hemolytic anemia , medicine , chronic lymphocytic leukemia , pure red cell aplasia , immunology , immune thrombocytopenia , leukemia , bone marrow , anemia , antibody
Chronic lymphocytic leukemia (CLL) is frequently complicated by secondary autoimmune cytopenias (AIC) represented by autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), pure red cell aplasia, and autoimmune granulocytopenia. The distinction of immune cytopenias from cytopenias due to bone marrow infiltration, usually associated with a worse outcome and often requiring a different treatment, is mandatory. AIHA and ITP are more frequently found in patients with unfavorable biological risk factors for CLL. AIC secondary to CLL respond less favorably to standard treatments than their primary forms, and treating the underlying CLL with chemotherapy or monoclonal antibodies may ultimately be necessary. Am. J. Hematol. 89:1055–1062, 2014. © 2014 Wiley Periodicals, Inc.