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Pregnancy complications predict thrombotic events in young women with essential thrombocythemia
Author(s) -
Randi Maria Luigia,
Bertozzi Irene,
Rumi Elisa,
Elena Chiara,
Finazzi Guido,
Vianelli Nicola,
Polverelli Nicola,
Ruggeri Marco,
Vannucchi Alessandro Maria,
Antonioli Elisabetta,
Lussana Federico,
Tieghi Alessia,
Iurlo Alessandra,
Elli Elena,
Ruella Marco,
Fabris Fabrizio,
Cazzola Mario,
Barbui Tiziano
Publication year - 2014
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.23635
Subject(s) - medicine , pregnancy , essential thrombocythemia , miscarriage , thrombosis , obstetrics , incidence (geometry) , myeloproliferative neoplasm , pediatrics , surgery , polycythemia vera , myelofibrosis , bone marrow , genetics , physics , optics , biology
Although Philadelphia‐negative myeloproliferative neoplasms (MPNs) occur typically in middle to advanced age, any age group may be affected, posing a challenge for their management during pregnancy when they occur in young females. There is a high incidence of thromboembolic events and pregnancy complications in patients with myeloproliferative neoplasms, and a possible relationship between these complications is a matter of concern. The aim of this article was to correlate thrombosis and pregnancy outcome in 158 females with ET experiencing 237 pregnancies. Seven patients had a thrombotic event before their first pregnancy, one of them ended (14.3%) in a miscarriage. Among the 151 patients with no history of thrombosis before they became pregnant, 40 (26.5%) had a miscarriage ( P = NS). Eighteen patients (11.4%) developed major thrombotic complications (12 splanchnic vein, 1 cerebral vein, 2 coronary syndromes, and 3 strokes) after at least one pregnancy (4 uneventful and 14 complicated). The occurrence of thrombosis was significantly more frequent ( P < 0.001) in patients with a history of pregnancy complications (28%) than in those experiencing a normal pregnancy and delivery (3.7%). Pregnancy complications in women with ET are associated with a higher risk of subsequent thromboses, so pregnant women with this neoplasm who miscarry need to be carefully monitored. Am. J. Hematol. 89:306–309, 2014. © 2013 Wiley Periodicals, Inc.