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Polymorphisms in DNA repair pathway genes, body mass index, and risk of non‐Hodgkin lymphoma
Author(s) -
Chen Yingtai,
Zheng Tongzhang,
Lan Qing,
Kim Christopher,
Qin Qin,
Foss Francine,
Chen Xuezhong,
Holford Theodore,
Leaderer Brian,
Boyle Peter,
Wang Chengfeng,
Dai Min,
Liu Zhenjiang,
Ma Shuangge,
Chanock Stephen J.,
Rothman Nathaniel,
Zhang Yawei
Publication year - 2013
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.23463
Subject(s) - xrcc1 , ercc2 , body mass index , lymphoma , dna repair , medicine , genotype , oncology , diffuse large b cell lymphoma , genetics , gene , biology , single nucleotide polymorphism
We conducted a population‐based case‐control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non‐Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T‐cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B‐cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk. Am. J. Hematol. 88:606–611, 2013. © 2013 Wiley Periodicals, Inc.