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Old and new prognostic factors in acute myeloid leukemia with deranged core‐binding factor beta
Author(s) -
Cairoli Roberto,
Beghini Alessandro,
Turrini Mauro,
Bertani Giambattista,
Nadali Gianpaolo,
Rodeghiero Francesco,
Castagnola Carlo,
Lazzaroni Francesca,
Nichelatti Michele,
Ferrara Felicetto,
Pizzolo Giovanni,
Pogliani Enrico,
Rossi Giuseppe,
Martinelli Giovanni,
Morra Enrica
Publication year - 2013
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.23461
Subject(s) - myeloid leukemia , medicine , oncology , core binding factor , beta (programming language) , cancer research , biology , transcription factor , gene , genetics , computer science , programming language
Acute myeloid leukemia (AML) with deranged core‐binding factor beta (CBFβ) is usually associated with a favorable prognosis with 50–70% of patients cured using contemporary treatments. We analyzed the prognostic significance of clinical features on 58 patients with CBFβ‐AML aged ≤60 years. Increasing age was the only predictor for survival ( P <0.001), with an optimal cut‐point at 43 years. White blood cells (WBCs) at diagnosis emerged as an independent risk factor for relapse incidence ( P = 0.017), with 1.1% increase of hazard for each 1.0 × 10 9 /L WBC increment. KIT mutations lacked prognostic value for survival and showed only a trend for relapse incidence ( P = 0.069). Am. J. Hematol. 88:594–600, 2013. © 2013 Wiley Periodicals, Inc.