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An unusual case of donor‐derived myelodysplastic syndrome following double‐unit umbilical cord blood transplantation in acute lymphoblastic leukemia
Author(s) -
Cotter Ryan,
Najfeld Vesna,
Isola Luis,
Del Toro Gustavo,
Roman Elizabeth,
Petersen Bruce,
Mascarenhas John
Publication year - 2012
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.23260
Subject(s) - medicine , transplantation , umbilical cord , minimal residual disease , acute lymphocytic leukemia , leukemia , immunology , umbilical cord blood transplantation , karyotype , hematology , gastroenterology , oncology , hematopoietic stem cell transplantation , biology , chromosome , lymphoblastic leukemia , genetics , gene
Umbilical cord-blood transplantation is considered an effective treatment strategy for acute lymphoblastic leukemia (ALL) when a human leukocyte antigen (HLA)-matched donor is unavailable. The use of a second unit helps ensure engraftment in larger adults and those with comorbidities, even though only one unit engrafts in most patients. Herein, we present the clinical and laboratory characteristics of a patient who developed donor-derived myelodysplastic syndrome (ddMDS) after double umbilical cord-blood transplantation (dUCB HSCT). To our knowledge, no cases of ddMDS have been described in a patient with a history of ALL in molecular remission after receiving a dUCB HSCT. Current molecular techniques, including analysis of short tandem repeats (STR) and fluorescence in situ hybridization (FISH) allowed us to firmly establish donor origin.