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Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non‐Hodgkin lymphoma
Author(s) -
Bi Xiaofeng,
Zheng Tongzhang,
Lan Qing,
Xu Zhijian,
Chen Yingtai,
Zhu Gongjian,
Foss Francine,
Kim Christopher,
Dai Min,
Zhao Ping,
Holford Theodore,
Leaderer Brian,
Boyle Peter,
Deng Qian,
Chanock Stephen J.,
Rothman Nathaniel,
Zhang Yawei
Publication year - 2012
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.23244
Subject(s) - odds ratio , lymphoma , medicine , genotype , blood transfusion , confidence interval , gastroenterology , whole blood , immunology , non hodgkin's lymphoma , biology , gene , genetics
We conducted a population‐based case‐control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non‐Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA ( rs9610 ) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1–3.2] or TNF ( rs1800629 ) AG/AA genotypes (OR = 1.6, 95% CI: 0.9–2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA ( rs9610 ) AG/AA genotypes (OR = 0.6, 95% CI: 0.4–0.9) or TNF ( rs1800629 ) GG genotype (OR = 0.7, 95% CI: 0.5–1.0). A similar pattern was also observed for B‐cell lymphoma but not for T‐cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA ( rs9610 ) ( P forinteraction = 0.003) and TNF ( rs1800629 ) ( P forinteraction = 0.012) for NHL overall and IL10RA ( rs9610 ) ( P forinteraction = 0.001) and TNF ( rs1800629 ) ( P forinteraction = 0.019) for B‐cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.