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Inherited genetic variation and overall survival following follicular lymphoma
Author(s) -
Gibson Todd M.,
Wang Sophia S.,
Cerhan James R.,
Maurer Matthew J.,
Hartge Patricia,
Habermann Thomas M.,
Davis Scott,
Cozen Wendy,
Lynch Charles F.,
Severson Richard K.,
Rothman Nathaniel,
Chanock Stephen J.,
Morton Lindsay M.
Publication year - 2012
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.23184
Subject(s) - follicular lymphoma , lymphoma , follicular phase , genetic variation , medicine , variation (astronomy) , oncology , biology , genetics , gene , physics , astrophysics
Follicular lymphoma (FL) has variable progression and survival, and improved identification of patients at high risk for progression would aid in identifying patients most likely to benefit from alternative therapy.In a sample of 244 FL cases identified during a population-based case-control study of non-Hodgkin lymphoma (NHL), we examined 6,679 tag SNPs in 488 gene regions for associations with overall FL survival. Over a median follow-up of 89 months with 65 deaths in this preliminary study, we identified 5 gene regions (BMP7, GALNT12,DUSP2, GADD45B, and ADAM17) that were associated with overall survival from FL. Results did not meet the criteria for statistical significance after adjustment for multiple hypothesis testing. These results,which support a role for host factors in determining the variable progression of FL, serve as an initial examination that can inform future studies of genetic variation and FL survival. However, they require replication in independent populations, as well as assessment in rituximab-treated patients.