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Elevated serum free light chains are associated with inferior event free and overall survival in Hodgkin lymphoma
Author(s) -
Thompson Carrie A.,
Maurer Matthew J.,
Cerhan James R.,
Katzmann Jerry A.,
Ansell Stephen M.,
Habermann Thomas M.,
Macon William R.,
Weiner George J.,
Link Brian K.,
Witzig Thomas E.
Publication year - 2011
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.22168
Subject(s) - immunoglobulin light chain , lymphoma , polyclonal antibodies , medicine , hodgkin lymphoma , dyscrasia , antibody , overall survival , plasma cell , gastroenterology , oncology , immunology
Abstract The serum free light chain (FLC) assay quantitates free immunoglobulin kappa and lambda light chains, which has prognostic value in plasma cell dyscrasias. However, there is limited data on serum FLC in lymphoid malignancies. We analyzed the association of pretreatment FLC with event‐free survival (EFS) and overall survival (OS) in 100 patients with Hodgkin lymphoma (HL). Elevated polyclonal FLC were present in 30% of patients; these patients had an inferior EFS (HR = 4.84; 95% CI: 1.84–12.7) and OS (HR = 8.87; 95% CI: 2.35–33.52) compared to patients with normal FLC. Further studies of FLC in HL are warranted. Am. J. Hematol., 2011. © 2011 Wiley‐Liss, Inc.