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Delayed G‐CSF stimulation after PBSCT does not seem to modify the biological parameters of bone marrow recovery
Author(s) -
Ianotto JeanChristophe,
Tempescul Adrian,
Delepine Pascal,
Guillerm Gaelle,
Hardy Elisabeth,
Eveillard JeanRichard,
Berthou Christian
Publication year - 2011
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21991
Subject(s) - medicine , multiple myeloma , bone marrow , stimulation , granulocyte colony stimulating factor , platelet , lymphoma , cd34 , hemoglobin , transplantation , gastroenterology , stem cell , surgery , chemotherapy , biology , genetics
There are currently no recommendations indicating when stimulation should begin after autologous peripheral blood stem cell transplantation (PBSCT). We compared the outcome following between two treatment groups, in which daily granulocyte colony stimulating factor (G‐CSF) administration began on either the fifth or the eighth day after PBSCT in lymphoma and myeloma patients. We studied eight clinical parameters: number of G‐CSF injections, number of days of hospitalization, of red blood cell or platelet transfusions; days when body temperature exceeds 38°C; days of parenteral nutrition; weight loss and hospitalization costs. We studied also four biological parameters: number of CD34+ cells, days with leucocytes less than 1 × 10 9 /L, days with hemoglobin less than 90 g/L or with less than 50 × 10 9 /L of platelets. There were no statistical significant differences between the study arms. It seems that delayed stimulation by G‐CSF after PBSCT is safety and does not seem to modify bone marrow recovery timing. Am. J. Hematol. 86:351–352, 2011. © 2011 Wiley‐Liss, Inc.