Premium
Hepcidin in anemia of chronic heart failure
Author(s) -
Divakaran Vijay,
Mehta Sachin,
Yao David,
Hassan Saamir,
Simpson Steven,
Wiegerinck Erwin,
Swinkels Dorine W.,
Mann Douglas L.,
AfsharKharghan Vahid
Publication year - 2011
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21902
Subject(s) - hepcidin , anemia , medicine , heart failure , pathogenesis , hemoglobin , inflammation , gastroenterology , immunology , endocrinology
Anemia is a common finding among patients with chronic heart failure (HF). Although comorbidities, such as kidney failure, might contribute to the pathogenesis of anemia, many patients with HF do not have any other obvious etiology for their anemia. We investigated whether anemia in HF is associated with an elevation in hepcidin concentration. We used time-of-flight mass spectrometry to measure hepcidin concentration in urine and serum samples of patients with HF and in control subjects. We found that the concentration of hepcidin was lower in urine samples of patients with HF compared with those of control subjects. Serum hepcidin was also reduced in HF but was not significantly lower than that in controls. There were no significant differences between hepcidin levels in patients with HF and anemia compared with patients with HF and normal hemoglobin level. We concluded that hepcidin probably does not play a major role in pathogenesis of anemia in patients with chronic HF.