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Alteration of cohesin genes in myeloid diseases
Author(s) -
Rocquain Julien,
GelsiBoyer Véronique,
Adélaïde José,
Murati Anne,
Carbuccia Nadine,
Vey Norbert,
Birnbaum Daniel,
Mozziconacci MarieJoelle,
Chaffanet Max
Publication year - 2010
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21798
Subject(s) - cohesin , biology , gene , genetics , myeloid , myelodysplastic syndromes , myeloid leukemia , cancer research , chromosome , bone marrow , immunology
New genes involved in leukemogenesis, such as ASXL1 and TET2, have been identified recently using genomic analyses of DNA from patient samples. We have studied by array-comparative genomic hybridization (aCGH) a series of 167 samples including myelodysplastic syndromes, chronic myelomonocytic leukemias, and acute myeloid leukemias. We found a deletion of the RAD21 and STAG2 genes, which encode two components of the cohesin complex. We propose that these alterations may compromise the cohesin complex and its regulation of the transcription of genes.