Premium
Acute life‐threatening cardiovascular toxicity with umbilical cord blood infusion: The role of dextran
Author(s) -
Ma Robert W.,
Kwan John M.,
Ma David D.,
Fay Keith C.
Publication year - 2010
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21797
Subject(s) - medicine , umbilical cord , adverse effect , dextran , toxicity , hematopoietic stem cell transplantation , haematopoiesis , transplantation , anesthesia , stem cell , pharmacology , surgery , immunology , chemistry , biochemistry , biology , genetics
Umbilical cord blood (UCB) is being increasingly used for hematopoietic stem cell transplantation due to its immediate availability. Dimethylsulfoxide (DMSO) and dextran-40 are commonly used for processing and cryopreservation of UCB. Adverse UCB infusion-related events are usually mild. However, reports of severe life-threatening events are now emerging. DMSO has been proposed as a possible cause of infusion-related reactions. In this report, we draw attention to an acute near-fatal reaction with UCB infusions resulting in myocardial ischemia and acute renal failure. We propose that dextran-40 in UCB infusion products be considered as a potential causative agent contributing to this infusion-related reaction, based on reports of known adverse reactions to dextran-40 in non-transplant settings.