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Response to Viana et al.
Author(s) -
Di Bartolomeo Paolo,
Santarone Stella,
Di Nicola Marta
Publication year - 2010
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21700
Subject(s) - intensive care unit , medicine , humanities , philosophy
International audienceTO THE EDITOR American Journal of Hematology Prof Carlo Brugnara There is no doubt that the observations made by Viana MB et al (Kaplan-Meyer method is inappropriate for estimating cumulative incidence of graft-versus-host disease in the presence of competing events) (American Journal of Hematology, 2010, in press) are relevant. Due to these suggestions, we have estimated again the graft-versus-host data as cumulative incidence and have compared them to those obtained with the Kaplan-Meyer method reported in our paper (Am J Hematol 2008;83:528-530). We found the following differences: Kaplan-Meyer methodCumulative incidence Acute GvHD grade I to IV37%35.6% Acute GvHD – CSA alone27%27% Acute GvHD – CSA + MTX54%P=0.001*51.2% P=0.002** Chronic GvHD17%14.8% *Log-rank test; ** Gray test The overestimation is minimal due the low number of failures of competing risks (early death before the possible occurrence of GvHD and graft rejection). Paolo Di Bartolomeo Stella Santarone Unità di Terapia Intensiva Ematologica per il Trapianto Emopoietico, Ospedale Civile, Pescara, Italy Marta Di Nicola Laboratorio di Biostatistica, Dipartimento di Scienze Biomediche, Università degli Studi, Chieti, Ital