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Reduced intensity conditioning regimen with fludarabine, busulfan, and low‐dose TBI (Flu‐BU2‐TBI): Clinical efficacy in high‐risk patients
Author(s) -
Takahata Mutsumi,
Hashino Satoshi,
Okada Kohei,
Onozawa Masahiro,
Kahata Kaoru,
Sugita Junichi,
Shigematsu Akio,
Kondo Takeshi,
Yamamoto Satoshi,
Endo Tomoyuki,
Nishio Mitsufumi,
Ito Yoichi M.,
Tanaka Junji,
Koike Takao,
Asaka Masahiro,
Imamura Masahiro
Publication year - 2010
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21630
Subject(s) - medicine , busulfan , total body irradiation , fludarabine , regimen , transplantation , surgery , hematopoietic stem cell transplantation , chemotherapy , cyclophosphamide
Reduced intensity conditioning (RIC) regimens are widely used in allogeneic stem cell transplantation (SCT). In this study, we retrospectively investigated the clinical outcomes of RIC with fludarabine (Flu; 180 mg/m 2 ), intravenous busulfan (BU; 6.4 mg/kg) or oral BU (8 mg/kg), and low‐dose total body irradiation (TBI; 4 Gy) (Flu‐BU2‐TBI) in 66 patients (median age: 54.5 years) with various hematological malignancies. Thirty‐eight patients (58%) were high‐risk patients (median age: 56 years). The overall survival rate at 2 years of the high‐risk patients was 64.5%, which was comparable to the survival rate of 70.9% in standard‐risk patients ( P = 0.68). The relapse rates at 2 years in the standard‐risk and high‐risk patients were 16 and 28%, respectively, and day 100 treatment‐related mortality rates were 0 and 6%, respectively. The Flu‐BU2‐TBI regimen for high‐risk patients showed therapeutic effects equivalent to those for standard‐risk patients and favorable outcomes compared with those of other previous RIC regimens. Am. J. Hematol., 2010. © 2010 Wiley‐Liss, Inc.