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Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of non‐Hodgkin lymphoma
Author(s) -
Li Yonghong,
Zheng Tongzhang,
Kilfoy Briseis A.,
Lan Qing,
Holford Theodore,
Han Xuesong,
Zhao Ping,
Dai Min,
Leaderer Brian,
Rothman Nat,
Zhang Yawei
Publication year - 2010
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21608
Subject(s) - lymphoma , alcohol consumption , alcohol , genetic variants , consumption (sociology) , computational biology , gene , genetics , computer science , biology , biochemistry , immunology , genotype , sociology , social science
The aim of this study was to investigate whether genetic polymorphisms in cytochrome P450s (CYPs), glutathione S-transferases (GSTs), and N-acetyltransferases (NATs) genes modify the relationship between alcohol consumption and risk of non-Hodgkin's lymphoma (NHL) in a population-based, case-control study including 1,115 Connecticut women. Although we did not find strong evidence that the genetic polymorphisms modify the relationship between alcohol consumption and risk of NHL, we identified significant interactions for multiple GSTs and NATs and alcohol intake among persons with DLBCL. Our results confer support investigation of the gene-environment interaction in a larger study population of DLBCL.