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Progressive transition of Epstein–Barr virus associated lymphoproliferative disease subtypes with the development of lung cancer
Author(s) -
Taoka Kazuki,
Nannya Yasuhito,
Yamamoto Go,
Sakatani Takashi,
Ota Satoshi,
Fukayama Masashi,
Takahashi Tsuyoshi,
Kurokawa Mineo
Publication year - 2009
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21479
Subject(s) - hematology , medicine , oncology , family medicine
Epstein-Barr virus (EBV) associated lymphoproliferative disease (LPD) comprises a wide spectrum of clinical and pathological features [1]. This variety is most systematically categorized in post-transplant lymphoproliferative disorders (PTLD) [2], in which subtypes are ordered according to disease progression from reactive polyclonal proliferation to large cell lymphoma. However, whether this categorization is applicable to LPDs other than PTLD is not well explored. Here, we present a nontransplant case of EBV-LPD that initially presented as a polyclonal self-limiting proliferation and later transited to large cell lymphoma. This transition was associated with the progression of lung cancer and its therapy. Our case demonstrates that stepwise progression of LPD is a feature that can be observed in non-PTLD cases of EBV-LPD.