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Decitabine combined with fractionated gemtuzumab ozogamicin therapy in patients with relapsed or refractory acute myeloid leukemia
Author(s) -
Chowdhury Saeeda,
Seropian Stuart,
Marks Peter W.
Publication year - 2009
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21478
Subject(s) - haven , medicine , gemtuzumab ozogamicin , hematology , family medicine , oncology , cd33 , mathematics , stem cell , combinatorics , biology , cd34 , genetics
Salvage chemotherapy for patients with relapsed or refractory acute myeloid leukemia (AML) is generally associated with a low-response rate and significant nonhematologic toxicity. Both decitabine and gemtuzumab ozogamicin have activity in AML as single agents and can be administered sequentially with potential synergy due to their toxicity profiles. Twelve patients with AML, who had received a median of three prior regimens (range 1-6), were treated with decitabine 20 mg/m(2) on days 1 through 5 followed by gemtuzumab ozogamicin 3 mg/m(2) on days 6, 9, and 12. Five patients achieved a complete response (42%) and subsequently underwent hematopoietic stem cell transplantation. Three patients are in complete remission and four are still alive 7 to 16 months after treatment. The regimen was well tolerated with the primary nonhematologic toxicity of Grade 1 or 2 transaminitis observed in four patients. These results indicate that decitabine in combination with gemtuzumab is a regimen of promising efficacy worthy of further investigation in controlled trials.