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Laboratory identification of lupus anticoagulants
Author(s) -
Smock Kristi J.,
Rodgers George M.
Publication year - 2009
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21417
Subject(s) - antiphospholipid syndrome , systemic lupus erythematosus , medicine , lupus anticoagulant , autoantibody , coagulation testing , gold standard (test) , immunology , intensive care medicine , coagulation , antibody , disease
Abstract Lupus anticoagulants (LA) are acquired autoantibodies that can cause antiphospholipid syndrome. LAs prolong phospholipid‐dependent coagulation tests, acting as nonspecific inhibitors that are neutralized in the presence of excess phospholipid. However, there is no gold standard test and the testing is influenced by a number of variables. This article summarizes laboratory testing for LAs, with particular focus on technical issues and limitations of testing. Am. J. Hematol. 2009. © 2009 Wiley‐Liss, Inc.