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Urinary cysteinyl leukotriene E 4 significantly increases during pain in children and adults with sickle cell disease
Author(s) -
Field Joshua J.,
Strunk Robert C.,
KnightPerry Jessica E.,
Blinder Morey A.,
Townsend R. Reid,
DeBaun Michael R.
Publication year - 2009
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21370
Subject(s) - leukotriene e4 , medicine , creatinine , leukotriene receptor , cohort , leukotriene , pathogenesis , gastroenterology , leukotriene d4 , disease , urinary system , immunology , asthma
Abstract Baseline level of the cysteinyl leukotriene (CysLT), leukotriene E 4 (LTE 4 ), is associated with an increased pain rate in children and adults with sickle cell disease (SCD). To provide additional evidence for a role of CysLTs in the pathogenesis of vaso‐occlusion, we tested the hypothesis that LTE 4 levels will increase within an individual during painful episodes compared to baseline. In a cohort of 19 children and adults with SCD, median LTE 4 levels increased from 82.36 pg/mg creatinine at baseline to 162.81 pg/mg creatinine during a painful episode ( P < 0.001). These data further support a contribution of CysLTs to the process of vaso‐occlusion. Am. J. Hematol., 2009. © 2009 Wiley‐Liss, Inc.