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Urinary cysteinyl leukotriene E 4 is associated with increased risk for pain and acute chest syndrome in adults with sickle cell disease
Author(s) -
Field Joshua J.,
Krings James,
White Nicole L.,
Yan Yan,
Blinder Morey A.,
Strunk Robert C.,
DeBaun Michael R.
Publication year - 2009
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21348
Subject(s) - acute chest syndrome , medicine , cohort , disease , chest pain , leukotriene e4 , gastroenterology , urinary system , sickle cell anemia , leukotriene , asthma
Leukotriene E 4 (LTE 4 ) levels are associated with rate of pain episodes in children with sickle cell disease (SCD). Because complications of SCD manifest differently in adults than children, we examined a cohort of adults with SCD to determine the relationship between baseline LTE 4 and SCD‐related morbidity. Baseline LTE 4 levels were associated with increased rates of pain and acute chest syndrome (ACS) episodes, when those with LTE 4 values in the highest tertile were compared with those in the lowest tertile (pain: risk ratio 7.1, 95% CI 1.8–27.5, P = 0.005; ACS: risk ratio 12.2, 95% CI 2.1–69.8, P = 0.005). Am. J. Hematol., 2009. © 2009 Wiley‐Liss, Inc.