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Laboratory testing for fibrinogen abnormalities
Author(s) -
Verhovsek Madeleine,
Moffat Karen A.,
Hayward Catherine P.M.
Publication year - 2008
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21293
Subject(s) - fibrinogen , fibrin , medicine , afibrinogenemia , coagulation , abnormality , coagulation disorder , pathology , immunology , psychiatry
Fibrinogen is essential for the formation of a fibrin clot. Acquired and congenital disorders of fibrinogen may result in decreased concentration or altered function of fibrinogen, often leading to an increased risk of bleeding. Routine coagulation testing and specialized laboratory investigations can guide diagnosis in patients suspected of having a fibrinogen abnormality. This article summarizes the types of laboratory assays that are used to assess fibrinogen disorders, and key abnormalities found in different types of fibrinogen disorders.disorders. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.