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A novel report of cig‐FISH and cytogenetics in POEMS syndrome
Author(s) -
Bryce Alan H.,
Ketterling Rhett P.,
Gertz Morie A.,
Lacy Martha,
Knudson Ryan A.,
Kumar Shaji,
Kyle Robert A.,
Fonseca Rafael,
Greipp Phillip R.,
Lust John A.,
Rajkumar Vincent S.,
Hayman Suzanne R.,
Buadi Francis,
Russell Stephen J.,
Zeldenrust Stephen R.,
Dispenzieri Angela
Publication year - 2008
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21285
Subject(s) - monosomy , poems syndrome , chromosomal translocation , trisomy , cytogenetics , fish <actinopterygii> , pathology , multiple myeloma , plasma cell , karyotype , medicine , cancer research , biology , gastroenterology , genetics , chromosome , gene , polyneuropathy , fishery
POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg‐FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg‐FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg‐FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.