Premium
Venous sinus thrombosis leading to stroke in a patient with sickle cell disease on hydroxyurea and high hemoglobin levels: Treatment with thrombolysis
Author(s) -
Sidani Charif A.,
Ballourah Walid,
El Dassouki Mohamad,
Muwakkit Samar,
Dabbous Ibrahim,
Dahoui Hanan,
AlKutoubi Aghiad,
Abboud Miguel R.
Publication year - 2008
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21261
Subject(s) - medicine , thrombolysis , thrombosis , stroke (engine) , surgery , venous thrombosis , hemoglobin , superior sagittal sinus , avascular necrosis , cardiology , myocardial infarction , mechanical engineering , femoral head , engineering
A 21‐year‐old man with homozygous sickle cell disease maintained on hydroxyurea for 1 year developed thrombosis of the superior sagittal, right transverse, and right sigmoid dural sinuses with a large venous infarct. He was successfully treated with endovascular thrombolysis. Investigation did not reveal any inherited or acquired hypercoagulable state. This patient however had consistently elevated hemoglobin levels both at the time of the initial event and on follow up. One year later he developed symptomatic avascular necrosis of the right hip. High hemoglobin levels resulting from hydroxyurea therapy may have contributed to development of complications in this patient. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.