Transfusion‐related acute lung injury following intravenous anti‐D administration in an adolescent | Zendy

BergerAchituv Sivan | Zendy; Ellis Martin H. | Zendy; Curtis Brian R. | Zendy; Wolach Baruch | Zendy

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Transfusion‐related acute lung injury following intravenous anti‐D administration in an adolescent

Author(s) -

BergerAchituv Sivan,

Ellis Martin H.,

Curtis Brian R.,

Wolach Baruch

Publication year - 2008

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.21185

Subject(s) - medicine , transfusion related acute lung injury , pulmonary edema , mechanical ventilation , thrombotic thrombocytopenic purpura , lung , anesthesia , gastroenterology , platelet

Transfusion‐related acute lung injury (TRALI) is associated with administration of all plasma containing blood products. We present a 14‐year‐old adolescent diagnosed with idiopathic thrombocytopenic purpura who developed acute respiratory insufficiency compatible with TRALI within 5 hr following intravenous anti‐D. Full blown noncardiogenic pulmonary edema was noted after 9 hr. Mechanical ventilation was not required and the patient made a full recovery after 36 hr. Analysis of the anti‐D preparation revealed reactivity against the neutrophil FcγRIIIb. A postinfusion serum sample contained antibodies against class I human HLA‐A11 antigen. Clinicians should consider TRALI in patients developing unexplained dyspnea after receiving intravenous anti‐D. Am. J. Hematol. 2008. © 2008 Wiley‐Liss, Inc.

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