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Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisis
Author(s) -
Landburg Precious P.,
Teerlink Tom,
Muskiet Frits A.J.,
Duits Ashley J.,
Schnog JohnJohn B.
Publication year - 2008
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21184
Subject(s) - asymmetric dimethylarginine , endogeny , nitric oxide synthase , nitric oxide , medicine , endocrinology , chemistry , pharmacology , arginine , biochemistry , amino acid
Plasma concentrations of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in the clinically asymptomatic state of sickle cell disease (SCD). However, the role of ADMA during vaso‐occlusive complications has not been defined. ADMA concentrations were determined in HbSS ( n = 43) and HbSC ( n = 25) patients with healthy blood donors (HbAA) as controls. In the clinically asymptomatic state ADMA concentrations were elevated in sickle cell patients as compared to healthy controls (HbSS 0.70 μmol/L, HbSC 0.54 μmol/L, HbAA 0.39 μmol/L) ( P < 0.001). Yet plasma ADMA concentrations did not increase further at presentation with a painful crisis implicating no role of primary importance during vaso‐occlusive crises. Am. J. Hematol. 2008. © 2008 Wiley‐Liss, Inc.