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Longitudinal analysis of pulmonary function in adults with sickle cell disease
Author(s) -
Field Joshua J.,
Glassberg Jeffrey,
Gilmore Annette,
Howard Joanna,
Patankar Sameer,
Yan Yan,
Davies Sally C.,
DeBaun Michael R.,
Strunk Robert C.
Publication year - 2008
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21176
Subject(s) - medicine , natural history , pulmonary function testing , sickle cell anemia , cohort , retrospective cohort study , disease , acute chest syndrome , cohort study , young adult , lung function , anemia , population , pediatrics , lung , environmental health
Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety‐two adults were included in this cohort. Rate of decline in FEV 1 for men and women with SCD was 49 cc/year (compared with 20–26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD. Am. J. Hematol. 2008. © 2008 Wiley‐Liss, Inc.