Premium
Flow cytometry in the diagnosis of drug‐induced thrombocytopenia: Two illustrative cases
Author(s) -
Scognamiglio Francesca,
Corso Chiara,
Madeo Domenico,
Castaman Giancarlo,
Visco Carlo,
Borghero Carlo,
Ruggeri Marco,
Rodeghiero Francesco
Publication year - 2008
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21111
Subject(s) - drug , medicine , context (archaeology) , abciximab , intensive care medicine , flow cytometry , identification (biology) , pharmacology , immunology , biology , myocardial infarction , paleontology , conventional pci , botany
Drug‐induced thrombocytopenia is a challenging diagnosis in the clinical practice because of the many drugs or alternative causes that may be implicated. Exact identification of such drug(s) is required to guide future management and avoid re‐exposure. We describe two cases of isolated thrombocytopenia in which cytometric analysis, a readily available technique, allowed the identification of the causative drug in the context of complex therapies (rifampicin and abciximab causing late onset thrombocytopenia). Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.