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Nodular lymphocyte predominant Hodgkin lymphoma at atypical locations may be associated with increased numbers of large cells and a diffuse histologic component
Author(s) -
Yang David T.,
Dunphy Cherie H.,
Tripp Sheryl R.,
Lagoo Anand S.,
Perkins Sherrie L.
Publication year - 2008
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21077
Subject(s) - lymphoma , component (thermodynamics) , lymphocyte , pathology , lymphocyte subsets , medicine , hodgkin lymphoma , immunology , t cell , immune system , physics , thermodynamics
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) typically affects predictable lymph node groups with excellent treatment outcomes, but cases with a diffuse histologic pattern are associated with recurrence and rarely, cases will transform to diffuse large B‐cell lymphoma. Although increased numbers of large cells has not been associated with poor prognosis, transformation is thought to histologically progress through a stage distinguished by increasing numbers of large atypical B‐cells. From 55 cases of NLPHL, we describe a possible subset of NLPHL occurring in older individuals at atypical sites, associated with increased numbers of large cells, a diffuse histologic component, and expression of Bcl‐2. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.