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Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease
Author(s) -
Taylor James G.,
Ackah Diana,
Cobb Crystal,
Orr Nick,
Percy Melanie J.,
Sachdev Vandana,
Machado Roberto,
Castro Oswaldo,
Kato Gregory J.,
Chanock Stephen J.,
Gladwin Mark T.
Publication year - 2008
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21035
Subject(s) - medicine , pulmonary hypertension , odds ratio , hemoglobinopathy , hemolysis , gastroenterology , thalassemia , sickle cell anemia , acute chest syndrome , risk factor , hemoglobin , hazard ratio , complication , pathogenesis , hemolytic anemia , cardiology , disease , confidence interval
Pulmonary hypertension is a common complication of sickle cell disease (SCD) and a risk factor for early death. Hemolysis may participate in its pathogenesis by limiting nitric oxide (NO) bioavailability and producing vasculopathy. We hypothesized that hemoglobin mutations that diminish hemolysis in SCD would influence pulmonary hypertension susceptibility. Surprisingly, coincident α‐thalassemia (Odds Ratio [OR] = 0.95, 95% CI = 0.46–1.94, P = NS) was not associated with pulmonary hypertension susceptibility in homozygous SCD. However, pulmonary hypertension cases were less likely to have hemoglobin SC (OR = 0.18, 95% confidence interval [CI] = 0.06–0.51, P = 0.0005) or Sβ + thalassemia (OR = 0.25, 95% CI = 0.06–1.16, P = 0.10). These compound heterozygotes may be protected from pulmonary hypertension because of reduced levels of intravascular hemolysis, but develop this complication at a lower rate possibly due to the presence of non‐hemolytic risk factors such as renal dysfunction, iron overload and advancing age. Despite this protective association, patients with SC who did develop pulmonary hypertension remained at significant risk for death during 49 months of follow‐up (Hazard Ratio = 8.20, P = 0.0057). Am. J. Hematol., 2008. Published 2007 Wiley‐Liss, Inc.