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Increased cerebral blood flow after leukapheresis for acute myelogenous leukemia
Author(s) -
Kasner Margaret T.,
Laury Adrienne,
Kasner Scott E.,
Carroll Martin,
Luger Selina M.
Publication year - 2007
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21006
Subject(s) - leukapheresis , medicine , leukemia , cerebral blood flow , biology , genetics , stem cell , cd34
Leukapheresis is often considered in the management of acute myelogenous leukemia (AML) with hyperleukocytosis and its sequelae, including myocardial infarction, pulmonary complications, and stroke. It is utilized on the assumption that leukapheresis improves blood rheology. We present a woman with AML and a history of meningioma encasing her left internal carotid artery. She presented with hyperleukocytosis and symptoms of ischemia. As her white blood cell continued to rise despite initiation of hydroxyurea therapy, she underwent leukapheresis emergently. Transcranial Doppler ultrasound demonstrated increased flow velocities in the left internal carotid and the right middle cerebral arteries, which normalized after leukapheresis. This is the first documentation that leukapheresis, in combination with hydroxyurea, improves cerebral hemodynamics in a patient with AML. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.