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Chlamydia psittaci infection and clinicopathologic analysis of ocular adnexal lymphomas in Korea
Author(s) -
Yoo Changhoon,
Ryu MinHee,
Huh Jooryung,
Park Ji Hyun,
Kang Hye Jin,
Ahn Hyo Sook,
Lee Yongjae,
Kim Myoung Joon,
Lee Hyoungnam,
Kim Tae Won,
Chang Heung Moon,
Lee JaeLyun,
Kang YoonKoo
Publication year - 2007
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20962
Subject(s) - chlamydia psittaci , medicine , chlamydia , lymphoma , gastroenterology , pathology , immunology
Ocular adnexal lymphoma (OAL) is a mostly extranodal marginal zone lymphoma (EMZL). Recent findings have suggested an association between Chlamydia psittaci (Cp ) infection and OAL. We sought to confirm this issue and to analyze the clinicopathologic characteristics of OAL in Korea. Between 1993 and 2004, 33 OAL cases were identified at the Asan Medical Center, Seoul, Korea. DNA was extracted from paraffin‐embedded tissues, and touchdown enzyme time release polymerase chain reaction was performed to identify three Chlamydia species ( Cp, C. tracomatis, and C. pneumoniae ). The same procedures were also performed in 21 samples from patients with non‐neoplastic ocular adnexal disease (NNOAD). All OAL cases were EMZL. Cp DNA was detected in 26/33 (79%) OAL samples compared with 5/21 (23%) NNOAD samples ( P < 0.001). With a median follow‐up of 38.5 months (range: 1–105 months), the 5‐year progression‐free survival (PFS) and overall survival (OS) rates of OAL patients were 72% and 93%, respectively. Clinicopathologic characteristics, recurrence rate, PFS, and OS were not associated with Cp infection. Our study demonstrates an association between OAL and Cp infection in Korea, suggesting that Cp plays a role as a causative antigen in Korean OAL patients. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.