Effect of treatment of  Strongyloides  infection on HTLV‐1 expression in a patient with adult T‐cell leukemia | Zendy

Ratner Lee | Zendy; Grant Christian | Zendy; Zimmerman Bevin | Zendy; Fritz Joseph | Zendy; Weil Gary | Zendy; Denes Alex | Zendy; Suresh Rama | Zendy; Campbell Nancy | Zendy; Jacobson Steve | Zendy; Lairmore Michael | Zendy

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Effect of treatment of Strongyloides infection on HTLV‐1 expression in a patient with adult T‐cell leukemia

Author(s) -

Ratner Lee,

Grant Christian,

Zimmerman Bevin,

Fritz Joseph,

Weil Gary,

Denes Alex,

Suresh Rama,

Campbell Nancy,

Jacobson Steve,

Lairmore Michael

Publication year - 2007

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.20929

Subject(s) - strongyloidiasis , coinfection , strongyloides stercoralis , leukemia , strongyloides , lymphoma , chronic leukemia , medicine , immunology , t cell leukemia , virology , human t lymphotropic virus 1 , adult t cell leukemia/lymphoma , virus , biology , acute leukemia , helminths

Human T‐cell leukemia virus type 1 (HTLV‐1) is associated with adult T‐cell leukemia–lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV‐1‐associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV‐1 replication by Strongyloides , which resolved with anti‐helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T‐cell stimulation. Am. J. Hematol. 82:929–931, 2007. © 2007 Wiley‐Liss, Inc.

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