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Effect of treatment of Strongyloides infection on HTLV‐1 expression in a patient with adult T‐cell leukemia
Author(s) -
Ratner Lee,
Grant Christian,
Zimmerman Bevin,
Fritz Joseph,
Weil Gary,
Denes Alex,
Suresh Rama,
Campbell Nancy,
Jacobson Steve,
Lairmore Michael
Publication year - 2007
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20929
Subject(s) - strongyloidiasis , coinfection , strongyloides stercoralis , leukemia , strongyloides , lymphoma , chronic leukemia , medicine , immunology , t cell leukemia , virology , human t lymphotropic virus 1 , adult t cell leukemia/lymphoma , virus , biology , acute leukemia , helminths
Human T‐cell leukemia virus type 1 (HTLV‐1) is associated with adult T‐cell leukemia–lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV‐1‐associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV‐1 replication by Strongyloides , which resolved with anti‐helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T‐cell stimulation. Am. J. Hematol. 82:929–931, 2007. © 2007 Wiley‐Liss, Inc.